Cal v. Louisville College Basketball 2025 Betting Odds and Lines

The California Golden Bears are underdogs in their match-up with the Louisville Cardinals, according to the latest odds

Haas Pavilion is home to the California Golden Bears (Courtesy: Cal Athletics)

The California Golden Bears are underdogs in their match-up with the Louisville Cardinals, according to the latest men’s college basketball lines and odds offered by sportsbooks.

Cal v. Louisville college basketball betting pick, odds and lines: Who is favored to win?

According to data independently collected by Write for California, the latest college basketball betting odds for Cal v. Louisville is between Cal +8.5 and Cal +9.5, as of Tuesday afternoon.

The Cal +9.5 line implies the California Golden Bears are about 10-point underdogs to the Louisville Cardinals.

According to data independently collected by Write for California, the latest point total for Cal v. Louisville college basketball “over-or-under” total score bets is between 159.5 and 160.5 points, as of Tuesday afternoon.

The Cal +9.5 line and 160.5-point total imply the California Golden Bears will lose to the Louisville Cardinals with a scoreline of about 85-75.

According to data independently collected by Write for California, the latest Cal v. Louisville college basketball “moneyline” ranges between Cal +295 and Cal +360 and Louisville -375 and Louisville -455, as of Tuesday afternoon.

Moneyline bets pay out based on the Cal v. Louisville college basketball game’s result, regardless of any point “spread” handicap or margin of victory.

A bet on Cal’s most favorable moneyline of Cal +360 pays a $360 profit with a $100 wager on a Cal victory because Cal is the underdog, while a wager on Louisville’s most favorable moneyline of Louisville -375 requires a $375 bet to earn a $100 wager because Louisville is the favorite to win.

Cal v. Louisville college basketball: What you should know

The Louisville Cardinals are ranked No. 13 in the coaches poll in the 2025-2026 men’s college basketball season, week nine rankings. Last week, Louisville was ranked No. 16 in the AP Poll and No. 14 in the coaches poll.

The California Golden Bears are 1-1 against the Louisville Cardinals in a short series which began in 2010. Cal lost its last match-up, 68-85, at Louisville last year on March 8, 2025. The contest was both teams’ first as Atlantic Coast Conference opponents.

Cal and Louisville have never played each other at Haas Pavilion in Berkeley, Calif.

The California Golden Bears have been on a nine-day holiday break. In its last game, on Dec. 21, Cal beat the Columbia Tigers of the Ivy League, 74-56, at home.

The Louisville Cardinals last played 10 days ago on Dec. 20, when they beat the Montana Grizzlies at home, 94-54. The then-ranked No. 11 Cardinals outscored the Grizzlies 54-24 in the second half after a back-and-forth first half.

The California Golden Bears are 11-1 in the 2025 men’s college basketball season, while the Louisville Cardinals are 10-2. Cal lost to Kansas State, 96-99, back on Nov. 13, while Louisville’s two losses were at No. 25 Arkansas (80-89) on Dec. 3 and at No. 20 Tennessee (62-83) on Dec. 16.

Cal has a perfect 11-0 record at home in Haas Pavilion this season, while Louisville is 2-2 on the road or when playing at neutral sites.

The California Golden Bears and Louisville Cardinals are both 6-3 against the spread in the 2025 men’s college basketball season.

Cal has had four “over” and five “under” games by total score in the 2025 men’s college basketball season. The Louisville Cardinals have had five “over” and four “under” games so far this season.

According to Vegas Insider, which reports sportsbooks’ offered odds and lines, the Cal v. Louisville men’s college basketball line opened Monday at about Cal +6.5. The Cal v. Louisville moneyline opened at about Cal +270 and Louisville -340, according to the odds aggregator.

Vegas Insider also reports the Cal v. Louisville total for “over-or-under” total score bets opened at about 158.5 points.

Two out of three bets (67%) on Cal v. Louisville with a point spread have been on the California Golden Bears, per Vegas Insider. Seventy-nine percent of Cal v. Louisville “over-or-under” total score bets have been on the “under,” and 94% of all Cal v. Louisville moneyline bets have been on the favorites, the Louisville Cardinals.

Bet responsibly. Odds and betting lines can change. Write for California provides betting information for context and entertainment purposes.

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