Big Game Cal v. Stanford College Football 2025 Betting Odds and Lines

The California Golden Bears are favorites to beat the Stanford Cardinal in the 128th Big Game, according to the latest odds

The California Golden Bears (6-4, 3-3 ACC) are favorites to win against the Stanford Cardinal (3-7, 2-5 ACC) in the 128th Big Game rivalry, according to the latest college football lines and odds offered by sportsbooks.

128th Big Game: Cal v. Stanford college football betting pick, odds and lines: Who is favored to win?

According to data independently collected by Write for California, the latest college football betting odds for Cal v. Stanford is between Cal -2.5 and Cal-3, as of Thursday morning.

The Cal -2.5 line implies the California Golden Bears are about three-point favorites compared to the Stanford Cardinal in the 128th Big Game rivalry match-up.

According to data independently collected by Write for California, the latest point totals for Cal v. Stanford college football “over-or-under” total score bets is a consensus 46.5 points, as of Thursday morning.

The Cal -2.5 line and 46.5-point total imply the California Golden Bears will defeat the Stanford Cardinal with a scoreline of about 25-22.

According to data independently collected by Write for California, the latest Cal v. Stanford college football “moneyline” ranges between Cal -142 and Cal -150 and Stanford +116 and Stanford +125, as of Thursday morning.

Moneyline bets pay out based on the Cal v. Stanford college football game’s result, regardless of any point “spread” handicap or margin of victory.

A bet on Cal’s most favorable moneyline of Cal -142 requires a $142 wager to earn a $100 profit, and a wager on Stanford’s most favorable moneyline of Stanford +125 pays a $125 profit on a $100 wager if the Cardinal earn an upset in the 128th Big Game.

128th Big Game: Cal v. Stanford college football: What you should know

Cal and Stanford meet Saturday, Nov. 22, 2025, for the 128th Big Game, one of the oldest rivalry games in college football. The California Golden Bears have a 51-65-11 all-time record in the Big Game, but have won four straight and five of the last six contests in the series.

Both Cal and Stanford sat idle last week on a bye week. In their last game, the California Golden Bears upset the No. 14 Louisville Cardinals in Kentucky, 29-26 in a down-to-the-wire overtime game, and Stanford lost 15-20 at North Carolina.

The 128th Big Game between Cal and Stanford will played on The Farm in Stanford, Calif. The California Golden Bears are 3-2 when away from home in the 2025 college football season, while the Stanford Cardinal are 3-1 at home.

According to Vegas Insider, which analyzes and aggregates sportsbooks’ offered odds and lines, the Cal v. Stanford college football line opened earlier this week at about Cal -4.5.

Vegas Insider reports the Cal v. Stanford moneyline opened earlier this week at about Cal -162 and Stanford +136. The Cal v. Stanford total opened earlier this week at about 48.5 points.

The California Golden Bears are 4-5 against the spread this season, while the Stanford Cardinal are 3-7 against the spread in the 2025 college football season.

According to Vegas Insider’s analysis, 76% of bets on the Cal v. Stanford college football game with a point spread have been on the California Golden Bears, totaling up to 87% of all dollars wagered. Vegas Insider also reports 90% of moneyline bets have been on the favorites, the California Golden Bears, but 69% of dollars bet on the moneyline have been on the Stanford Cardinal.

Bet responsibly. Odds and betting lines can change. Write for California provides betting information for context and entertainment purposes.

If you or someone you know has a gambling problem, help is available at 1-800-GAMBLER.