Cal v. Duke College Football 2025 Betting Odds and Lines
The California Golden Bears are slight underdogs to the Duke Blue Devils, according to the latest odds

The California Golden Bears (4-1, 1-0 ACC) are slight underdogs against the Duke Blue Devils (3-2, 2-0 ACC), according to the latest sportsbooks’ college football lines and odds.
Cal v. Duke college football betting pick, odds and lines: Who is favored to win?
According to data independently collected and viewed by Write for California, the latest college football betting odds for Cal v. Duke is between Cal +2.5 and Cal +3, as of Wednesday morning.
The Cal +2.5 line implies the California Golden Bears are about a three-point underdog to the Duke Blue Devils.
According to data independently collected and viewed by Write for California, the latest point totals for Cal v. Duke college football “over-or-under” total score bets are between 55.5 and 56.5 points, as of Wednesday morning.
The Cal +2.5 line and 56.5-point total imply the Duke Blue Devils will beat the California Golden Bears with a scoreline of approximately 30-27.
Cal v. Duke college football “moneyline” bets range between Cal +116 and Cal +130 and Duke -143 and Duke -155, according to data independently collected and viewed by Write for California, as of Wednesday morning.
Moneyline bets pay out based on the Cal v. Duke college football game’s result, regardless of the margin of victory or the “point spread” handicap.
A bet on Cal’s most favorable moneyline of Cal +130 pays $230 on a $100 moneyline bet if Cal wins for a profit of $130. In contrast, a moneyline bet on Duke’s most favorable odds of Duke -143 pays a profit of $100 on a $143 wager.
Cal v. Duke college football: What you should know
The California Golden Bears have a 0-1-1 record against the Duke Blue Devils. In the last meeting, Cal played Duke to a 22-22 draw on Oct. 12, 1963, in Berkeley, Calif.
Last week, the Duke Blue Devils beat the Syracuse Orange, 38-3, at the JMA Wireless Dome in Syracuse, N.Y., while the California Golden Bears won 28-24 at Boston College.
Cal and Duke are facing each other for the first time this Saturday evening as conference opponents. The California Golden Bears joined the Atlantic Coast Conference last season.
According to Vegas Insider, which analyzes and aggregates sportsbooks’ college football odds and lines, the Cal v. Duke college football line opened earlier this week at about California +1.5. Over the week, the spread moved a point and a half against Cal, meaning bettors believe Duke will win. Circa Sports’ line opened this past Sunday at Cal +2. Vegas Insider reports the Cal v. Duke moneyline opened early this week at about California +105 and Duke -125.
The California Golden Bears are 3-1 against the spread this season, while Duke has a 2-2 record when a point handicap is considered.
Cal has had one “over” result and three “under” matches under the point-total, while Duke has had three “over” and one “under” games this season.


We are underdogs probably because of the loss to San Diego State and also the loss of McCulloch (OLB) and Crosby (DB). These two were very important parts of the defense that was so good against Minnesota.
Ain't touching this one!