Cal v. Louisville College Football 2025 Betting Odds and Lines
The California Golden Bears are underdogs in their match-up against the Louisville Cardinals, according to the latest odds
The California Golden Bears (5-4, 2-2 ACC) are underdogs in their match-up against the No. 14 Louisville Cardinals (7-1, 4-1 ACC), according to the latest college football lines and odds offered by sportsbooks.
Cal v. Louisville college football betting pick, odds and lines: Who is favored to win?
According to data independently collected by Write for California, the latest college football betting odds for Cal v. Louisville is a consensus Cal +20.5, as of Wednesday afternoon.
The Cal +20.5 line implies the California Golden Bears are about 21-point underdogs to the Louisville Cardinals.
According to data independently collected by Write for California, the latest point totals for Cal v. Louisville college football “over-or-under” total score bets is a consensus 50.5 points, as of Wednesday afternoon.
The Cal +20.5 line and 50.5-point total imply the California Golden Bears will lose to the Louisville Cardinals with a scoreline of about 36-15.
According to data independently collected by Write for California, the latest Cal v. Louisville college football “moneyline” ranges between Cal +700 and Cal +920 and Louisville -1100 and Louisville -1800, as of Wednesday afternoon.
Moneyline bets pay out based on the Cal v. Louisville college football game’s result, regardless of any point “spread” handicap or margin of victory.
A bet on Cal’s most favorable moneyline of Cal +920 pays a $920 profit with a $100 wager, and a wager on Louisville’s most favorable moneyline of Louisville -1100 requires a $1,100 bet to win $100.
Cal v. Louisville college football: What you should know
The California Golden Bears and Louisville Cardinals meet for the first time on Saturday, Nov. 8, 2025.
Cal last played against a nationally ranked top-25 team last week, when they lost to the No. 15 Virginia Cavaliers, 21-31. The Golden Bears travel to Louisville, Ky., this weekend to face the No. 14 Louisville Cardinals. Cal has not beat a top-25 team since December 5, 2020.
The California Golden Bears are 2-2 on the road this season, while the Louisville Cardinals are 4-1 at home.
Last week, Louisville beat Virginia Tech in Blacksburg, Va., 28-16. The Cardinals scored 21 unanswered points in the second half to secure the come-from-behind win over the Hokies.
According to Vegas Insider, which analyzes and aggregates sportsbooks’ offered odds and lines, the Cal v. Louisville college football line opened earlier this week at about Cal +17.5.
Vegas Insider reports the Cal v. Louisville moneyline opened earlier this week at about Cal +800 and Louisville -1350. The Cal v. Louisville total opened earlier this week at about 50.5 points, unchanged from the latest offered total.
The California Golden Bears are 3-5 against the spread this season, while the Louisville Cardinals are 3-4 against the spread in the 2025 college football season.
According to Vegas Insider’s analysis, 54% of bets on the Cal v. Louisville college football game with a point spread have been on the California Golden Bears, totaling up to 60% of all dollars wagered. Vegas Insider also reports 98% of moneyline bets and money wagered have been on the favorites, the Louisville Cardinals.
That is a heck of a spread but doesn't seem that far off. OK, so we all have our ways of dealing with Cal football. This Saturday afternoon I will be stacking firewood and will come inside for breaks and watch a bit of the game. Then I will probably be pissed off again and go stack more wood. The anger keeps me moving. I will have the full cord stacked by nightfall. It's kinda sick. Go Bears anyway.
safe travels team